Journal of Pathology and Translational Medicine

Case Study

Ovarian Gynandroblastoma with a Juvenile Granulosa Cell Tumor Component in a Postmenopausal Woman: A Case Report and Literature Review: Nu Ri Jang, Dae Hyung Lee, Eun Jung Jang, Young Kyung Bae, Jina Baek, Min Hye Jang; J Pathol Transl Med. 2018;52(5):344-348. Published online July 17, 2018; DOI: https://doi.org/10.4132/jptm.2018.06.28

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Gynandroblastoma is an extremely rare sex cord-stromal tumor with both female (granulosa cell tumor) and male (Sertoli-Leydig cell tumor) elements. Juvenile granulosa cell tumors are also very rare and are so named because they usually occur in children and adolescents. A 71-year-old woman with right upper quadrant abdominal pain visited our hospital. Pelvic computed tomography showed a large multilocular cystic mass, suspected to be of ovarian origin. We performed a total abdominal hysterectomy (total abdominal hysterectomy was performed) with bilateral salpingooophorectomy. A 13-cm multilocular cystic mass with serous fluid was observed in her right ovary. Upon microscopic examination, the solid component of the mass showed both Sertoli-Leydig cell and juvenile granulosa cell differentiation, which we diagnosed as gynandroblastoma. Gynandroblastoma with a juvenile granulosa cell tumor component is extremely rare and, until now, only six cases have been reported in the English literature. We report the first gynandroblastoma with a juvenile granulosa cell tumor component diagnosed in an elderly patient, along with a literature review.

Citations

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Ovarian Gynandroblastoma with a Juvenile Granulosa Cell Tumor Component in a Postmenopausal Woman
Soohyun Hwang, Byoung-Gie Kim, Sang Yong Song, Hyun-Soo Kim
Diagnostics.2020; 10(8): 537. CrossRef
Clinical and histological criteria for sex cord ovarian stromal tumors
A. М. Beishembaev, K. I. Zhordania
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Original Articles

Interobserver Variability of Ki-67 Measurement in Breast Cancer: Yul Ri Chung, Min Hye Jang, So Yeon Park, Gyungyub Gong, Woo-Hee Jung, The Korean Breast Pathology Ki- Study Group; J Pathol Transl Med. 2016;50(2):129-137. Published online February 15, 2016; DOI: https://doi.org/10.4132/jptm.2015.12.24

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Abstract PDF

Background
As measurement of Ki-67 proliferation index is an important part of breast cancer diagnostics, we conducted a multicenter study to examine the degree of concordance in Ki-67 counting and to find factors that lead to its variability. Methods: Thirty observers from thirty different institutions reviewed Ki-67–stained slides of 20 different breast cancers on whole sections and tissue microarray (TMA) by online system. Ten of the 20 breast cancers had hot spots of Ki-67 expression. Each observer scored Ki-67 in two different ways: direct counting (average vs. hot spot method) and categorical estimation. Intraclass correlation coefficient (ICC) of Ki-67 index was calculated for comparative analysis. Results: For direct counting, ICC of TMA was slightly higher than that of whole sections using average method (0.895 vs 0.858). The ICC of tumors with hot spots was lower than that of tumors without (0.736 vs 0.874). In tumors with hot spots, observers took an additional counting from the hot spot; the ICC of whole sections using hot spot method was still lower than that of TMA (0.737 vs 0.895). In categorical estimation, Ki-67 index showed a wide distribution in some cases. Nevertheless, in tumors with hot spots, the range of distribution in Ki-67 categories was decreased with hot spot method and in TMA platform. Conclusions: Interobserver variability of Ki-67 index for direct counting and categorical estimation was relatively high. Tumors with hot spots showed greater interobserver variability as opposed to those without, and restricting the measurement area yielded lower interobserver variability.

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Applied Immunohistochemistry & Molecular Morphology.2024; 32(3): 119. CrossRef
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Expression of estrogen and progesterone receptors, HER2 protein and Ki-67 proliferation index in breast carcinoma in both tumor tissue and tissue microarray
UP Hacısalihoğlu, MA Dogan
Biotechnic & Histochemistry.2022; 97(4): 298. CrossRef
Diffusive Ki67 and vimentin are associated with worse recurrence-free survival of upper tract urothelial carcinoma: A retrospective cohort study from bench to bedside
Che Hsueh Yang, Wei Chun Weng, Yen Chuan Ou, Yi Sheng Lin, Li Hua Huang, Chin Heng Lu, Tang Yi Tsao, Chao Yu Hsu, Min Che Tung
Urologic Oncology: Seminars and Original Investigations.2022; 40(3): 109.e21. CrossRef
Should Ki-67 be adopted to select breast cancer patients for treatment with adjuvant abemaciclib?
P. Tarantino, H.J. Burstein, N.U. Lin, I.E. Krop, E.P. Winer, S.J. Schnitt, E.P. Hamilton, S.A. Hurvitz, H.S. Rugo, G. Curigliano, S.M. Tolaney
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Tojo Mathew, S. Niyas, C.I. Johnpaul, Jyoti R. Kini, Jeny Rajan
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Matthias Choschzick, Mariam Alyahiaoui, Alexander Ciritsis, Cristina Rossi, André Gut, Patryk Hejduk, Andreas Boss
Heliyon.2021; 7(7): e07577. CrossRef
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Divya Meermira, Meenakshi Swain, Swarnalata Gowrishankar
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Darshana Govind, Kuang-Yu Jen, Karen Matsukuma, Guofeng Gao, Kristin A. Olson, Dorina Gui, Gregory. E. Wilding, Samuel P. Border, Pinaki Sarder
Scientific Reports.2020;[Epub] CrossRef
Practical approaches to automated digital image analysis of Ki-67 labeling index in 997 breast carcinomas and causes of discordance with visual assessment
Ah-Young Kwon, Ha Young Park, Jiyeon Hyeon, Seok Jin Nam, Seok Won Kim, Jeong Eon Lee, Jong-Han Yu, Se Kyung Lee, Soo Youn Cho, Eun Yoon Cho, Irina V. Lebedeva
PLOS ONE.2019; 14(2): e0212309. CrossRef
Evaluation of Ki-67 Index in Core Needle Biopsies and Matched Breast Cancer Surgical Specimens
Soomin Ahn, Junghye Lee, Min-Sun Cho, Sanghui Park, Sun Hee Sung
Archives of Pathology & Laboratory Medicine.2018; 142(3): 364. CrossRef
Assessment of Ki-67 for Predicting Effective Prognosis in Breast Cancer Subtypes
Sangjung Park, Sunyoung Park, Jungho Kim, Sungwoo Ahn, Kwang Hwa Park, Hyeyoung Lee
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Anne‐Sofie Wessel Lindberg, Knut Conradsen, Rasmus Larsen, Michael Friis Lippert, Rasmus Røge, Mogens Vyberg
Cytometry Part A.2017; 91(6): 574. CrossRef
A comparison of Ki-67 counting methods in luminal Breast Cancer: The Average Method vs. the Hot Spot Method
Min Hye Jang, Hyun Jung Kim, Yul Ri Chung, Yangkyu Lee, So Yeon Park, William B. Coleman
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Review of Medical Advisory Services by the Korean Society of Pathologists from 2003 to 2014: Min Hye Jang, Geon Kook Lee, Han Seong Kim, Wan Seop Kim; J Pathol Transl Med. 2016;50(1):37-44. Published online November 17, 2015; DOI: https://doi.org/10.4132/jptm.2015.09.18

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Abstract PDF Supplementary Material: Background
Since 2003, the Korean Society of Pathologists (KSP) has been officially providing medical advisory services (MAS). We reviewed the cases submitted to the KSP between 2003 and 2014. Methods: In total, 1,950 cases were submitted, most by private health insurance companies. The main purposes of the consultations were to clarify the initial diagnoses and to assign a proper disease classification code. We comprehensively reviewed 1,803 consultation cases with detailed information. Results: In spite of some fluctuations, the number of submitted cases has been significantly increasing over the 12 study years. The colon and rectum (40.3%), urinary bladder (14.2%), and stomach (6.9%) were the three most common tissues of origin. The most common diagnoses for each of the three tissues of origin were neuroendocrine tumor (50.7%), non-invasive papillary urothelial carcinoma (70.7%), and adenocarcinoma (36.2%). Regardless of the tissue of origin, neuroendocrine tumor of the digestive system was the most common diagnosis (419 of 1,803). Conclusions: In the current study, we found that pathologic consultations associated with private health insurance accounted for a large proportion of the MAS. Coding of the biologic behavior of diseases was the main issue of the consultations. In spite of the effort of the KSP to set proper guidelines for coding and classification of tumors, this review revealed that problems still exist and will continue to be an important issue.

The Diagnostic Usefulness of HMGA2, Survivin, CEACAM6, and SFN/14-3-3 δ in Follicular Thyroid Carcinoma: Min Hye Jang, Kyeong Cheon Jung, Hye Sook Min; J Pathol Transl Med. 2015;49(2):112-117. Published online March 12, 2015; DOI: https://doi.org/10.4132/jptm.2015.01.31

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Abstract PDF

Background
Follicular thyroid carcinoma (FTC) is the second most common thyroid malignancy and its differential diagnosis includes follicular adenoma (FA) and adenomatous goiter (AG). Several ancillary markers have been suggested to aid in the diagnosis of FTC, but the successful use of these methods still needs to be validated. Methods: In the present study, we verified the immunoexpression of HMGA2, CEACAM6, survivin, and SFN/14-3-3 δ in lesions including 41 AGs, 72 FAs, and 79 FTCs. We evaluated their diagnostic usefulness, combined with galectin 3, Hector Battifora mesothelial 1 (HBME1), cytokeratin 19, and cyclin D1, in diagnosing FTC. Results: The expressions of HBME1 (65.8%) and HMGA2 (55.7%) were significantly higher in FTCs than in FAs and AGs (p<.001 and p=.005, respectively). HBME1 was the only marker that was more frequently expressed in FTCs than in FAs (p=.021) and it was more frequently expressed in follicular neoplasms than in AGs (p<.001). Among the novel markers, the combination of HMGA2 and HBME1 showed the highest sensitivity (72.2%) and specificity (76.1%) for diagnosing FTC. CEACAM6, survivin, and SFN/14-3-3 δ were barely expressed in most cases. Conclusions: Our present results show that only HMGA2 can be beneficial in differentiating FTC using the novel markers.

Citations

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HMGA2 promotes nasopharyngeal carcinoma progression and is associated with tumor resistance and poor prognosis
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miR‐98‐5p promotes apoptosis and inhibits migration and cell growth in papillary thyroid carcinoma through Bax/Caspase‐3 by HMGA2
Kai Qiu, QingJi Xie, Shan Jiang, Ting Lin
Journal of Clinical Laboratory Analysis.2020;[Epub] CrossRef
High mobility group A protein-2 as a tumor cancer diagnostic and prognostic marker: a systematic review and meta-analysis
Yen Thi-Hai Pham, Ovie Utuama, Claire E. Thomas, Jong A. Park, Carlo La Vecchia, Harvey A. Risch, Chi Thi-Du Tran, Thanh V. Le, Paolo Boffetta, Leon Raskin, Hung N. Luu
European Journal of Cancer Prevention.2020; 29(6): 565. CrossRef
Diagnostic performance of HMGA2 gene expression for differentiation of malignant thyroid nodules: A systematic review and meta‐analysis
Bo Hyun Kim, Seong Jang Kim, Mijin Kim, Sang‐Woo Lee, Shin Young Jeong, Kyoungjune Pak, Keunyoung Kim, In Joo Kim
Clinical Endocrinology.2018; 89(6): 856. CrossRef
Thyroid follicular adenomas and carcinomas: molecular profiling provides evidence for a continuous evolution
Geneviève Dom, Sandra Frank, Sebastien Floor, Pashalina Kehagias, Frederick Libert, Catherine Hoang, Guy Andry, Alex Spinette, Ligia Craciun, Nicolas de Saint Aubin, Christophe Tresallet, Frederique Tissier, Frederique Savagner, Samira Majjaj, Ilse Gutier
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APLP2, RRM2, and PRC1: New Putative Markers for the Differential Diagnosis of Thyroid Follicular Lesions
Esmeralda Castelblanco, Carles Zafon, Javier Maravall, Pilar Gallel, Montserrat Martinez, Ismael Capel, Maria Rosa Bella, Irene Halperin, Jordi Temprana, Carmela Iglesias, Manel Puig-Domingo, Mercedes Robledo, Xavier Matias-Guiu, Didac Mauricio
Thyroid.2017; 27(1): 59. CrossRef
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Yourha Kim, Min-Hee Kim, Sora Jeon, Jeeyoon Kim, Chankyung Kim, Ja Seong Bae, Chan Kwon Jung, Yves St-Pierre
PLOS ONE.2017; 12(3): e0174737. CrossRef
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Oncology Letters.2017; 13(4): 2437. CrossRef
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Duško Dunđerović, Jasmina Marković Lipkovski, Ivan Boričic, Ivan Soldatović, Vesna Božic, Dubravka Cvejić, Svetislav Tatić
Diagnostic Pathology.2015;[Epub] CrossRef

Case Report

Invasive Cribriform Carcinoma Arising in Malignant Phyllodes Tumor of Breast: A Case Report: Yoomi Choi, Kyoung Yul Lee, Min Hye Jang, Hyesil Seol, Sung-Won Kim, So Yeon Park; Korean J Pathol. 2012;46(2):205-209. Published online April 25, 2012; DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.2.205

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Abstract PDF

Phyllodes tumor is an uncommon fibroepithelial neoplasm of the breast. And it is characterized by expanded stroma with increased cellularity and elongated epithelium-lined clefts. Mammary carcinomas within phyllodes tumors have been rarely reported. To date, however, no reports have described the invasive cribriform carcinoma arising in malignant phyllodes tumor. Here, we report a 62-year-old woman who presented with a large breast mass. Microscopically, the mass was a typical malignant phyllodes tumor showing well developed leaf-like architecture and stromal overgrowth with high cellularity and nuclear pleomorphism. In a portion of the tumor, however, the epithelial component showed a cribriform pattern of proliferation in the absence of myoepithelial cells, suggestive of the invasive cribriform carcinoma. To our knowledge, this is rare and it is difficult to make a differential diagnosis of it. Here, we report our case with a review of literatures.

Citations

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Management of Concurrent Malignant Phyllodes Tumor and Invasive Breast Carcinoma
Jie Jane Chen, Iowis Zhu, Akshat Patel, Gregor Krings, Yunn-Yi Chen, Florence Yuen, Rita A. Mukhtar, Michelle Melisko, Lisa Singer, Catherine C. Park, Nicolas D. Prionas
Advances in Radiation Oncology.2024; 9(5): 101448. CrossRef
High-grade ductal carcinoma in-situ detected by microcalcification within borderline phyllodes tumor: Report of a case and literature review
Wing Nam Yuen, Joshua J.X. Li, Man Yi Chan, Gary M. Tse
Human Pathology Reports.2023; 31: 300697. CrossRef
Cribriform carcinoma arising in a benign phyllodes tumor
EliaShazniza Shaaya, Nurwahyuna Rosli, Nurismah MD Isa
Journal of Research in Medical Sciences.2023; 28(1): 16. CrossRef
Unexpectedly High Coexistence Rate of In Situ/Invasive Carcinoma In Phyllodes Tumors. 10-Year Retrospective and Review Study
Öykü Dila Gemci, Serdar Altınay, Rümeysa İlbar Tartar, Sina Ferahman
European Journal of Breast Health.2022; 18(4): 343. CrossRef
A Case of Phyllodes Tumor Combined with Lobular Carcinoma of the Breast with Microinvasion
Daiki IMANISHI, Satoru NODA, Tsutomu TAKASHIMA, Yukie TAUCHI, Shinya NOMURA, Hiroshi OHTANI, Noriko SAKAIDA
Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association).2022; 83(12): 2049. CrossRef
Invasive ductal carcinoma within borderline phyllodes tumor with lymph node metastases: A case report and review of the literature
DI WU, HAIPENG ZHANG, LIANG GUO, XU YAN, ZHIMIN FAN
Oncology Letters.2016; 11(4): 2502. CrossRef

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